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ADENOCARCINOMA / AIDS LYMPHOMA / BREAST / BRAIN TUMOR
BREAST, HEAD, NECK, DEEP TUMORS / INFLAMM. BREAST /
PROSTATE / SINUS SARCOMA / TONSIL
Breast Cancer I
Breast Cancer
Breast Cancer II
Breast Cancer III
Breast Cancer Treatment
Please follow this link to see pictures
of Breast Cancer Treatment resuls, bellow.
Scientific Paper presented by Dr. James Bicher in the International Clinical Hyperthermia
Society, in Lyon. France, June 2000.
MORE HEAT AND LESS RADIATION
HYPERFRACTIONATION IS KEY IN THE
SUCCESFULLL TREATMENT OF MALIGNANT TUMORS
James I. Bicher, M. D.
Valley Cancer Institute, Los Angeles, CA, U.S.A |
| Hyperthermia has been proven to increase the
response of malignant tumors to radiation therapy in both experimental animal tumors and
the clinical treatment of human cancer. Based on our multi-year experience, first in
re-treatment of previously radiated fields that necessitated the use of low dose radiation
fractions as adjunct to the heat treatments, and then progressively applying the
encouraging results obtained to areas treated "de novo" and eventually to
situations allowing a potentially curative intent, treatment protocols have been devised
and tested that yield positive preliminary data showing superior tumor response rates and
less side effects when compared with historical controls at our Institute.
The hyperthermia part of the protocol extends the number of heat
treatments to correspond to the number of radiation-fractions, as each hyperthermia
treatment proceeds or follows each radiation treatment in close time proximity. The number
of hyperthermia treatments therefore varies from 25-50 per course for each treated field.
The radiation protocol consists of progressively decreasing daily doses
of radiation therapy combined with the daily hyperthermia treatments. Typically the
treatment is started at a daily dose of 180cGy gradually reduced to 100cGy protracting a
typical radiation therapy treatment course from 5000cGy in five weeks to 5000cGy given in
over eight weeks; or 7000cGy in seven weeks to 7000cGy in 14 weeks. According to the ELLIS
TDF formula, this results in a 15% or 25% reduction of the effective radiation dose. The
total dose is of course adapted to the clinical situation. |
| The following Conclusions are drawn:
CONCLUSIONS
Protracted Hyperfractionation
- Decreases the radiation dose by 15% and 24%.
- Decreases the side effects of XRT (no diarrhea, fistula or pneumonitis in PH cases)
- Allows for more combined XRT-Hyperthermia treatments
- Increases the effectiveness of the combined treatment in superficial and deep tumors.
Question: What is the lowest radiation dose needed to potentiate
Hyperthermia?
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Pictures
of Breast Cancer Treatment
One patient's result. These pictures were taken before and after the Breast Cancer
treatment with Hyperthermia, combined with low radiation dose.
Before treatment, 06·03·99
After two months of treatment, 08·12·99
 
On 02·01·2000
On 02·16·2000
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