The following table reflect the results obtain at
the Valley Cancer Institute, Dr James I. Bicher director, in the last 5
years, 2004 through February 2009.
Breast Cancer treatment results has been
consistent at the Valley Cancer institute in the last 25 years, using
daily Hyperthermia plus low dose or fractionated radiation. Alternative cancer treatment, alternative breast cancer treatment,
alternative prostate cancer treatment.
This another very entertaining video
testimonial of a Breast Cancer Survival patient. Again this patient did
not wanted to go through the "very rough time my mother went with
chemotherapy and radiation", "I was looking for a low dose radiation
treatment, when I found Valley Cancer Institute..."
"I'm leaving Valley Cancer Institute,
Because the doctors released me and they said that all my tests came
back cancer free. So I’m back to my 100% good self".
We had added the precision and extremely localized
modality of radiation treatment called IMRT (Intensity modulated
Radiation Therapy) in the last 12 months, which in combination with the
gentle Hyperthermia treatment makes a very powerful and effective alternative of cancer treatment. This excellent
combination not only provides a more efficient cancer treatment
with curative intent, but prevents radiation to affect healthy
tissue that surrounds the body area to be treated.
Side effects are minimum and most times not even
noticeable, since the body has ample time to recover from the effects of
the low and localized radiation portion of the whole treatment.
Hyperthermia has practically no side effect, other than a little red
skin on very sensitive patients in very few cases.Alternative cancer treatment, alternative breast cancer treatment,
alternative prostate cancer treatment.
Hyperthermia combined with low IMRT radiation
therapy, is one of the best cancer treatment alternatives available now
days, because of the high response rates and low or non
side effects. A proof of that are the extensive research and treatments that
Duke University has been doing in the last two years. Dr. James
Bicher had worked on this efficient modality of cancer treatment with
curative intent, since 1983, for over 36 years. The clinical results
obtained wit Hyperthermia combined with low dose radiation, had been
consistent over all that period of time, giving Valley Cancer Institute
a long proven record of excellent results, in most cases, has the
Treatment Results Table shows below.
Hyperthermia has a long proven record of
effectiveness and very low or no side effects.
Breast Cancer Treatment
PicturesAlternative cancer treatment, alternative breast cancer treatment,
alternative prostate cancer treatment.
One patient's result. These pictures were taken before and after the Breast Cancer
treatment with Hyperthermia, combined with low radiation dose. Alternative cancer treatment, alternative breast cancer treatment,
alternative prostate cancer treatment.
Pictures of Breast cancer patients treated with Hyperthermia
and very low radiation dose (means very low side effects and
that the body can easily recover by
it self without toxic medications) :
HyperthermiaBreast Cancer Treatment: Before treatment,
10·09·91
We want to know your opinion on
causes of Breast Cancer, and you best tips or ways you believe it can be
avoided. Please follow
this link to the Survey, at the bottom of this page
Scientific paper published in the
German Journal of Hyperthermia, on 2006.
THERMORADIOTHERAPY WITH CURATIVE
INTENT
BREAST, HEAD
AND NECK AND PROSTATE TUMORS
JAMES I. BICHER, M.D., NAZAR Al-BUSSAM, M.D. and RALPH S. WOLFSTEIN,
M.D.
Valley Cancer Institute, Los Angeles, California U.S.A.
Alternative cancer treatment, alternative
breast cancer treatment, alternative prostate cancer treatment.
AbstractAlternative cancer treatment,
alternative breast cancer treatment, alternative prostate cancer treatment.
Purpose: To evaluate the effectiveness of hyperfractionated
thermoradiotherapy (HTRT) in patients suffering from early stage of breast cancer, head
and neck cancer and prostate cancer that refuse conventional radiation surgery or
chemotherapy. Response rates and survival were determined using objective end points.
(MRI, MRS, PET scan and tumor markers).
Alternative
cancer treatment, alternative breast cancer treatment, alternative prostate cancer
treatment.
Material and Methods: Fractionation used involved daily
hyperthermia treatments in conjunction with each radiation fraction. Radiation daily doses
are progressively decreased from 180 to 100 cGy resulting in protracted treatment time
that decreases the isoeffect biological equivalent dose by 15% to 25%. This decrease is
compensated by the increased number of hyperthermia fractions which potentiates each
radiation dose. Treatment is continued until an objective complete response is attained,
or failure determined. 40 breast cancer patients, 17 head and neck cancer and 15 prostate
cancer patients were treated with a follow up of two to five years. All patients were
early stage (III-a or less).Alternative cancer
treatment, alternative breast cancer treatment, alternative prostate cancer treatment.
Results: Complete response rates were 82% for breast cancer
patients, 88% for head and neck cancer and 93% for prostate cancer patients. Projected 5
year survival rates were 80% for breast cancer patients, 88% for head and neck, 87% for
prostate patients. Side effects were less than with curative radiation therapy alone. No
Grade IV toxicity (Common Toxicity Criteria) was observed.Alternative cancer treatment, alternative breast cancer treatment,
alternative prostate cancer treatment.
Conclusion: Protracted hyperfractionation of daily
thermoradiotherapy decreases the side effects of radiation therapy, allows treating to
effect using objective end point parameters, accomplishes a high percentage of complete
responses and a high 5-year survival rate in the 80-90% range in early superficial tumors.
It can be considered as potentially curative in Stage I-II breast cancer, head and neck
and prostate cancer when used and researched as such.
Keywords: Cancer, head and neck, breast, prostate, hyperthermia,
radiation, survival, head and neck cancer, breast cancer, prostate cancer
IntroductionAlternative
cancer treatment, alternative breast cancer treatment, alternative prostate cancer
treatment.
That hyperthermia potentiates radiation therapy has been proven in
malignant cancers, metastatic nodes in the head and neck region [1-6] and several other
locations [7-9]. Due to these early findings, clinical applications were limited to
recurrent advanced or metastatic cancers [10-12]. However, prospective randomized trials
in the 1990's demonstrated the effectiveness of thermoradiotherapy not only in superficial
tumors but also when deeper structures are affected [13-14] provided these tumors can be
effectively heated. The addition of heat roughly doubles the effectiveness of radiation,
but also the fact that hyperthermia increases tumor oxygenation [15-16, 41] makes hypoxic
tumors such as sarcomas or glioblastomas more susceptible to thermoradiotherapy [17].
In previous publications [18] we described a treatment regimen based on
protraction of the radiation fractionation combined with daily hyperthermia treatments
coinciding with each radiation dose. This regimen is effective in eradicating tumors with
diminished toxicity.
Based on our early experience as well as the vast literature available,
we undertook to treat accessible tumors "de novo" with curative intent in a
subgroup of patients that explicitly refused other accepted cancer treatment modalities,
including classic radiation therapy, surgery and chemotherapy. The areas chosen were
breast cancer, head and neck and prostate cancer.Alternative
cancer treatment, alternative breast cancer treatment, alternative prostate cancer
treatment.
Material and MethodsAlternative
cancer treatment, alternative breast cancer treatment, alternative prostate cancer
treatment.
1.Hyperthermia Equipment and Technique - Hyperthermia treatments
were delivered using either microwave or ultrasound FDA approved equipment. Microwaves
were delivered using a BSD-1000 machine with an MA-100 applicator at 600 MHz (BSD Medical
Corporation, Salt Lake City, Utah) or a Cheung Laboratories Machine (Columbia, MD)
operating at 915 MHz using its air cooled applicators. Temperature measurements were done
using disposable micro thermocouple pairs (150 micron size sensors) (DANBI, Inc., Los
Angeles, CA) inserted through a 20 gauge plastic catheter placed in the tumor region,
providing at least 3 different measuring points. Another probe is placed on the skin
above. Temperatures were recorded using P.C. computers connected to the thermocouples
through an Omega Engineering temperature acquisition board. Ultrasound hyperthermia was
induced using a Labthermics machine (Labthermics, Champagne, IL) using appropriate
applicators (large - 15 cm x 15 cm, 3MHz and 1 MHz; small-7.5 cm x 7.5 cm,3Mhz and 1 MHz),
and the same thermometry devices as described above. Breast cancer and head and neck
tumors were treated either with microwave or ultrasound. Prostate tumors using ultrasound
only.
2.Hyperthermia Fractionation and Treatment Plan - Hyperthermia
treatments of one hour each were delivered daily, 5 days/week for 16 to 20 weeks, to the
tumor and involved nodal areas, within one hour of each radiation fraction. Hyperthermia
was given either before or after radiation. The treated area was divided into 2 or more
adjacent fields sequentially treated. Most patients received 2 daily heat treatment, one
to each field. The target temperature was 41.5o C, usually achieved at least in
2 of the measurement points. Temperatures were heterogeneous within the tumors. The
hyperthermia part of the protocol extends the number of heat treatments to correspond to
the number of radiation fractions, as each hyperthermia treatment precedes or follows each
radiation treatment. The number of hyperthermia treatments therefore varies from 25-50 per
course for each treatment field.Alternative cancer
treatment, alternative breast cancer treatment, alternative prostate cancer treatment.
3.Radiation Therapy Technique - Radiation therapy was delivered
using a Mevatron 12 Siemens machine (Siemens Medical Solutions USA, Inc., Malvern, PA)
operating at 10 MeV. Tumors were treated to primary and lymph drainage areas using
standard treatment plans for each of the treated tumors; and accepted quality assurance
procedures.
4.Radiation Therapy Fractionation - The radiation protocol
consists of progressively decreasing daily doses of radiation therapy combined with the
daily hyperthermia treatments. Typically the treatment is started at a daily dose of 180
cGy gradually reduced to 100 cGy protracting a typical radiation therapy treatment course
from 5000 cGy in five weeks to 5000 cGy given in over eight weeks or 7000 cGy in seven
weeks to 7000 cGy in 14 weeks. (See Table 1) According to the ELLIS TDF formula ([19] this
results in a 15% or 25% reduction of the effective radiation dose. The total dose is of
course adapted to the clinical situation. To this effect, the use of objective end result
parameters is introduced, including MRI, MR Spectroscopy [20], PET Scanning,
Table 1. Radiation Therapy Fractionation
Conventional Fractions
200 x 25 = 5,000
TDF = 82
35 x 200 = 7,000
TDF = 115
Protracted Hyperfractionation
[cGy]
TDF
[cGy]
TDF
180 X 10 = 1800
28
180 X 10 = 1800
28
150 X 10 = 1500
21
150 X 10 = 1500
21
120 X 10 = 1200
15
120 X 10 = 1200
15
100 X 5 = 500
6
100 X 10 = 1000
11
50 X 30 = 1500
12
35 Fx = 5000
70
70 Fx = 7000
87
Tumor Markers and PSA levels. Typically, the
treatment is continued with further reduced doses until all the objective parameters
confirm a complete response or failure is determined. Therefore, as opposed to classic
radiation therapy, patients are treated to effect as objectively demonstrated, instead of
to a pre-determined radiation dose or number of fractions.
5.Patient Population - Tumors Treated. - Patients included in
this study belong to a subpopulation that refuses all standard medical treatments,
including clinical radiation therapy, surgery and chemotherapy . All signed appropriate
consent forms. Only patients with early stage III or below with a potential for
eradication of localized disease were included. The tumors chosen were breast cancer, head
and neck or prostate cancer confined to an anatomical location allowing for accessible
technically feasible heat delivery.
StatisticsAlternative cancer
treatment, alternative breast cancer treatment, alternative prostate cancer treatment.
All tests were done with Graph Pad Prism 4 software (Graph Pad Software
Inc., San Diego, USA) using the method of Kaplan and Meier.
ResultsAlternative cancer
treatment, alternative breast cancer treatment, alternative prostate cancer treatment.
Complete response rates were gratifying when compared with published
results of thermoradiotherapy or our previous experience [6, 13, 21-26]. Breast cancer
tumors showed a complete response rate (CR) of 82% with 7% partial responders (PR). (See
Table 2) The CR rate for head and neck tumors was 88% (See Table 3) and for prostate
tumors 93% (See Table 4)Alternative cancer
treatment, alternative breast cancer treatment, alternative prostate cancer treatment.
Perhaps the most notable advantage of the daily hyperthermia
fractionation regimen combined with diminishing radiation fraction size is that treatment
may be continued until an objectively documented response (tumor markers, MRI or CT and
PET scan) is obtained. This approach eliminates the "damp and pray" paradigm of
classic radiation therapy for a more benign, but potentially more effective way to
eradicate early stage reachable tumors. By using this approach in this study we achieved a
high degree of documented complete responses with much less toxicity than that observed
when using high doses of radiation. This is particularly remarkable in head and neck
tumors. None of our patients required gastric intubation and only two required feeding
tubes.
In spite of good clinical results the question arises of the role of
thermotolerance (TT) in the proposed treatment regimen. TT is a well recognized phenomenon
[27-28,31] diminishing the effectiveness of successive hyperthermia treatments in cells in
vitro or in vivo in experimental animals [29-30], after a first priming heat dose. This
protection to the cell kill elicited by a second heat dose seems to last 43 to 72 hours,
and is the basis for the twice a week hyperthermia regimen practiced in most hyperthermia
clinics.
However, several arguments can be raised to explain the good results
obtained when using the daily hyperfractionated regimen in present results as well as in
previously reported direct comparisons between 2 versus 5 weekly fractions when treating
superficial as well as deep tumors, [22-23]. They include the following points:
(a) Radiation eliminates thermotolerance. The development of
thermotolerance is much less or does not occur at all if each heat treatment is directly
preceded by an x-ray dose, as reported by Streffer et al [32-33] when studying the effect
of thermoradiotherapy on micronuclei formation on tumor melanoma cells. These findings are
in good agreement with other reports in the literature [34].
(b) Chronic thermotolerance is not expressed in many human cells. Studies
by Mackey et al [35-36] clearly demonstrated lack of development of chronic
thermotolerance in several lines of normal and transformed human cells, including He La S3
and Molt-4 lines. The clinical work of Machovsky, [37-39] who obtained outstanding
regression of tumors in patients suffering from glioblastoma multiformes treated with
interstitial hyperthermia alone continuously for periods of 90 hours or more also negate a
role for TT in the clinical setting, for TT presence would off negated any effectiveness
for the prolonged treatment, which in concept is similar to our protracted
hyperfractionation. It should also be noted that Hornback et al accomplished excellent
clinical results when using daily hyperthermia fractions [11].
(c) Low pH negates thermotolerance. In previous publications
[15, 40] we demonstrated a lowering of intratumor pH following hyperthermia treatments, a
finding since confirmed [40-41] in different experimental settings [33]. Streffer, Leeper,
et al [42] and Gerwick et al [43, 44] demonstrated that under low pH conditions, the
phenomenon of thermotolerance is greatly diminished or absent. The microvascular changes
associated with hyperthermia that lead to the pH drop [45] should then be considered of
importance in the clinical setting.
(d) Reoxygenation. Another metabolic consequence of the
hyperthermic induced microvascular changes are fluctuations in the level of tissue
oxygenation, as we described early on and has since been confirmed [15, 46]. As tissue
temperature rises, there is a rise in Tp O2, which peaks at about 42oC
and is followed by a decrease in oxygenation. 42oC is then considered the tumor
microvascular breaking point and is lower in tumors than in normal tissues [15, 41]. Since
in real clinical practice the tissue temperatures obtained seldom exceed 41.5oC
when using externally induced heating, we are operating in the hypermic, hyperoxic phase
and increases in Tp O2 has indeed been documented during
hyperthermia treatments [47-48]. These facts have led Song et al [46] to propose that
reoxygenation may be the main mechanism for the hyperthermic potentiation of radiation
induced cell kill, as ionizing radiation is more effective in oxygenated cells [17]. The
elevated oxygen levels in human tumors have been demonstrated to last upwards of 24 hours
[47], again justifying the effectiveness of daily hyperthermia treatments.
The current results are gratifying and compare well with prior
thermoradiotherapy literature when treating recurrent tumors - a strong correlation seems
to exist between the total radiation dose complete response and tumor control rate. Perez
and associates[51] reported a 40% complete response rate in patients who
received less than 32 Gy compared with 67% for patients who received 32 to 40 Gy. Valdagni
and colleagues reported no complete responses with doses of 10 to 29 Gy, 50% with 30 to 39
Gy, and 67% for 44 to 49 Gy. [6].
In studies of locally advanced neck disease (no prior irradiation)
reported by Valdagni and colleagues [6]] and Datta and co-workers.[50] both of which used
conventionally fractionated irradiation (64 to 70 Gy in Valdagni and 60 to 65 Gy in
Datta). Hyperthermia was administered twice weekly. Both studies showed an improved
complete response with hyperthermia (82.3% versus 36.8% Valdagni and 55% versus 31%
Datta). It was associated with improved long-term freedom from relapse in both studies. In
a recent publication Valdagni [6] estimated the probability of 5-year survival in patients
receiving thermoradiotherapy for stage IV recurrent neck nodes at 53.3%, versus 0% for
patients treated with radiation alone. Similar 3-year survival was recently reported by
Welz et al [49] when treating recurrent chest wall disease in breast cancer. The 3-year
survival rate was 85% and disease free survival rate 69%.
Recent publications by Kaplan et al [52], Anscher et al [53] and,
Kalopurakal et al [24] described a high percentage of complete responses and long survival
when combining external radiation therapy with local hyperthermia in treating advanced or
recurrent adenocarcinoma of the prostate. Of particular notice is a paper by Algan et al
[26] that reports a 5-year 0S (overall survival) of 73%, with a median survival of 88
months in similar cases.
The safety and efficacy of thermoradiotherapy has been often proved,
but a reluctance still exists to make the modality part of the initial treatment plan even
in patients with tumors that are technically easy to heat. Relegating the role of such a
promising and relatively less toxic modality runs counter to the wishes of patients and
the hopes of oncologists. Our results open the possibility of abandoning the old paradigm
of using thermoradiotherapy only on advanced or recurrent tumors doomed to long term
failure by definition, and use it in early cases where its true value in the oncology
armamentarian could eventually be established.
The "cure of breast cancer" or "breast cancer
cure" are one of the most used keywords in Google now days. That speaks by
itself, of the seriousness of this heath conditions.
If you search for the cure of breast
cancer on line or off line, you will find that radiation alone,
chemotherapy, and surgery are still the main stream treatments offered.
But more and more people are aware of the limited efficacy of
those historically well established cancer treatments.
There are many organization that
still ask for donations in the name of "The Search for The Breast Cancer
Cure". Millions of dollar wasted on finding the magic drug that will
wipe with some pills, in a few days or months, a health condition that
took years to develop.
Some of the causes that make the
healthy body cells to mutate into cancer cells, are:
Pollution, air, water, food, sun
Nutrition, or better the lack of
it
Food poisoned with fertilizers,
"food enhancers", food colorants, food mutation, etc.
Working with cancerigenous
chemical, substances without knowing
Chronic health issues, like
constipation, liver overworked, organs overloaded with toxins, etc.
______________________________________________________________________________________________________________________________________________________________________________ Call for more information: (310)398-0013,
and ask for Nash. Thanks
