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Scientific paper published in the German Journal of Hyperthermia, on 2006.

THERMORADIOTHERAPY WITH CURATIVE INTENT

BREAST, HEAD AND NECK AND PROSTATE TUMORS

Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Abstract Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Purpose: To evaluate the effectiveness of hyperfractionated thermoradiotherapy (HTRT) in patients suffering from early stage of breast cancer, head and neck cancer and prostate cancer that refuse conventional radiation surgery or chemotherapy. Response rates and survival were determined using objective end points. (MRI, MRS, PET scan and tumor markers). Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Material and Methods: Fractionation used involved daily hyperthermia treatments in conjunction with each radiation fraction. Radiation daily doses are progressively decreased from 180 to 100 cGy resulting in protracted treatment time that decreases the isoeffect biological equivalent dose by 15% to 25%. This decrease is compensated by the increased number of hyperthermia fractions which potentiates each radiation dose. Treatment is continued until an objective complete response is attained, or failure determined. 40 breast cancer patients, 17 head and neck cancer and 15 prostate cancer patients were treated with a follow up of two to five years. All patients were early stage (III-a or less). Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Results: Complete response rates were 82% for breast cancer patients, 88% for head and neck cancer and 93% for prostate cancer patients. Projected 5 year survival rates were 80% for breast cancer patients, 88% for head and neck, 87% for prostate patients. Side effects were less than with curative radiation therapy alone. No Grade IV toxicity (Common Toxicity Criteria) was observed. Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Conclusion: Protracted hyperfractionation of daily thermoradiotherapy decreases the side effects of radiation therapy, allows treating to effect using objective end point parameters, accomplishes a high percentage of complete responses and a high 5-year survival rate in the 80-90% range in early superficial tumors. It can be considered as potentially curative in Stage I-II breast cancer, head and neck and prostate cancer when used and researched as such.

Keywords: Cancer, head and neck, breast, prostate, hyperthermia, radiation, survival, head and neck cancer, breast cancer, prostate cancer

Introduction Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

That hyperthermia potentiates radiation therapy has been proven in malignant cancers, metastatic nodes in the head and neck region [1-6] and several other locations [7-9]. Due to these early findings, clinical applications were limited to recurrent advanced or metastatic cancers [10-12]. However, prospective randomized trials in the 1990's demonstrated the effectiveness of thermoradiotherapy not only in superficial tumors but also when deeper structures are affected [13-14] provided these tumors can be effectively heated. The addition of heat roughly doubles the effectiveness of radiation, but also the fact that hyperthermia increases tumor oxygenation [15-16, 41] makes hypoxic tumors such as sarcomas or glioblastomas more susceptible to thermoradiotherapy [17].

In previous publications [18] we described a treatment regimen based on protraction of the radiation fractionation combined with daily hyperthermia treatments coinciding with each radiation dose. This regimen is effective in eradicating tumors with diminished toxicity.

Based on our early experience as well as the vast literature available, we undertook to treat accessible tumors "de novo" with curative intent in a subgroup of patients that explicitly refused other accepted cancer treatment modalities, including classic radiation therapy, surgery and chemotherapy. The areas chosen were breast cancer, head and neck and prostate cancer. Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Material and Methods Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

1.Hyperthermia Equipment and Technique - Hyperthermia treatments were delivered using either microwave or ultrasound FDA approved equipment. Microwaves were delivered using a BSD-1000 machine with an MA-100 applicator at 600 MHz (BSD Medical Corporation, Salt Lake City, Utah) or a Cheung Laboratories Machine (Columbia, MD) operating at 915 MHz using its air cooled applicators. Temperature measurements were done using disposable micro thermocouple pairs (150 micron size sensors) (DANBI, Inc., Los Angeles, CA) inserted through a 20 gauge plastic catheter placed in the tumor region, providing at least 3 different measuring points. Another probe is placed on the skin above. Temperatures were recorded using P.C. computers connected to the thermocouples through an Omega Engineering temperature acquisition board. Ultrasound hyperthermia was induced using a Labthermics machine (Labthermics, Champagne, IL) using appropriate applicators (large - 15 cm x 15 cm, 3MHz and 1 MHz; small-7.5 cm x 7.5 cm,3Mhz and 1 MHz), and the same thermometry devices as described above. Breast cancer and head and neck tumors were treated either with microwave or ultrasound. Prostate tumors using ultrasound only.

2.Hyperthermia Fractionation and Treatment Plan - Hyperthermia treatments of one hour each were delivered daily, 5 days/week for 16 to 20 weeks, to the tumor and involved nodal areas, within one hour of each radiation fraction. Hyperthermia was given either before or after radiation. The treated area was divided into 2 or more adjacent fields sequentially treated. Most patients received 2 daily heat treatment, one to each field. The target temperature was 41.5^o C, usually achieved at least in 2 of the measurement points. Temperatures were heterogeneous within the tumors. The hyperthermia part of the protocol extends the number of heat treatments to correspond to the number of radiation fractions, as each hyperthermia treatment precedes or follows each radiation treatment. The number of hyperthermia treatments therefore varies from 25-50 per course for each treatment field. Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

3.Radiation Therapy Technique - Radiation therapy was delivered using a Mevatron 12 Siemens machine (Siemens Medical Solutions USA, Inc., Malvern, PA) operating at 10 MeV. Tumors were treated to primary and lymph drainage areas using standard treatment plans for each of the treated tumors; and accepted quality assurance procedures.

4.Radiation Therapy Fractionation - The radiation protocol consists of progressively decreasing daily doses of radiation therapy combined with the daily hyperthermia treatments. Typically the treatment is started at a daily dose of 180 cGy gradually reduced to 100 cGy protracting a typical radiation therapy treatment course from 5000 cGy in five weeks to 5000 cGy given in over eight weeks or 7000 cGy in seven weeks to 7000 cGy in 14 weeks. (See Table 1) According to the ELLIS TDF formula ([19] this results in a 15% or 25% reduction of the effective radiation dose. The total dose is of course adapted to the clinical situation. To this effect, the use of objective end result parameters is introduced, including MRI, MR Spectroscopy [20], PET Scanning,

Conventional Fractions

Tumor Markers and PSA levels. Typically, the treatment is continued with further reduced doses until all the objective parameters confirm a complete response or failure is determined. Therefore, as opposed to classic radiation therapy, patients are treated to effect as objectively demonstrated, instead of to a pre-determined radiation dose or number of fractions.

5.Patient Population - Tumors Treated. - Patients included in this study belong to a subpopulation that refuses all standard medical treatments, including clinical radiation therapy, surgery and chemotherapy . All signed appropriate consent forms. Only patients with early stage III or below with a potential for eradication of localized disease were included. The tumors chosen were breast cancer, head and neck or prostate cancer confined to an anatomical location allowing for accessible technically feasible heat delivery.

Statistics Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

All tests were done with Graph Pad Prism 4 software (Graph Pad Software Inc., San Diego, USA) using the method of Kaplan and Meier.

Results Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Complete response rates were gratifying when compared with published results of thermoradiotherapy or our previous experience [6, 13, 21-26]. Breast cancer tumors showed a complete response rate (CR) of 82% with 7% partial responders (PR). (See Table 2) The CR rate for head and neck tumors was 88% (See Table 3) and for prostate tumors 93% (See Table 4)Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Table 2. Response Rate of Breast Cancer Patients

Table 3. Response Rate of Head and Neck Cancer Patients

Dissemination rates were comparable. They were 23% for breast cancer tumors (Table 2)13% for head and neck (Table 3) and 14% for prostate tumors (Table 4)

 Table 4. Response Rate of Prostate Cancer Patients

Projected 5 year survival rates are depicted in Tables 5 and 6. They are 80% for breast cancer patients, 88% for head and neck and 87% for prostate patients. Side effects were commensurable with the biological equivalent of radiation doses given. Dermatitis and occasional thermal burns (61% of treatments in breast cancer patients). Nausea, vomiting and occasional diarrhea and cystitis when treating pelvic fields in prostate patients; mucositis, thickness of saliva and altered taste during head and neck treatment. Hyperthermia did not seem to add to the radiation early effects. In all, the treatment was well tolerated on the vast majority of the patients.

The potentiation of radiation by the addition of heat treatments has been extensively demonstrated, both experimentally and in clinical studies [1-14]. Early patient studies were mainly done in recurrent nodes in chest wall or neck locations [1-3, 5, 11] as well as cutaneous deposits of malignant melanoma or lymphoma [7, 23]. Since most of these recurrences followed failure of high dose radiation, hyperthermia was combined with low dose radiation. In general the responses were better with heat and low doses of radiation than with mega doses of radiation alone [6, 23]. Recent publications by Valdagni, [6 ] and Weltz [49] reported high percentage of long term survival for recurrent breast cancer and head and neck tumors, respectively. Based on these early results and our own experience [8-9, 21-23, 30] as well as several prospective randomized trials proving the safety and efficacy of thermoradiotherapy [13-14, 24] we undertook to treat "de novo" a subpopulation of patients that refused conventional treatment.

• Decreases the radiation dose by 15 to 25%

• Decreases the side effects of radiation therapy

• Allows treating to effect using objective end point parameters (tumor markers, PET scans, MRI, etc.)

• Accomplishes a high percentage of complete responses in superficial tumors

• Accomplishes a high 5-year survival rate in the 80-90% range in early superficial tumors

• Is potentially curative in early stage breast cancer, head and neck and prostate cancers

Response Rate of Breast Cancer Patients Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Response Rate of Head and Neck Cancer Patients Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Response Rate of Prostate Cancer Patients Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Survey: The cure of Breast Cancer

The "cure of breast cancer" or "breast cancer cure" are one of the most used keywords in Google now days. That speaks by itself, of the seriousness of this heath conditions.

If you search for the cure of breast cancer on line or off line, you will find that radiation alone, chemotherapy, and surgery are still the main stream treatments offered. But more and more people are aware  of the limited efficacy of those historically well established cancer treatments.

There are many organization that still ask for donations in the name of "The Search for The Breast Cancer Cure". Millions of dollar wasted on finding the magic drug that will wipe with some pills, in a few days or months, a health condition that took years to develop.

Some of the causes that make the healthy body cells to mutate into cancer cells, are:

• Pollution, air, water, food, sun

• Nutrition, or better the lack of it

• Food poisoned with fertilizers, "food enhancers", food colorants, food mutation, etc.

• Working with cancerigenous chemical, substances without knowing

• Chronic health issues, like constipation, liver overworked, organs overloaded with toxins, etc.

• Emotional problems

• According with "The China study" by Joel Fuhrman, M.D, meat consumption

• Smoking and second hand smoking

Reader's suggestions

• Toxic environment, physically, mentally, emotionally, and spiritually
  by Daniel, 12-08-08

• "Leave your suggestion in the box below"

• Eating organic foods, free of pesticides, fertilizers, "foreign" and toxic chemicals
• Exercising; just a daily walk can make a big difference
• Eliminate unnecessary stress. All stress is unnecessary, but some activities that cause it, are really unnecessary
• Emotional support
• Avoid toxins in your body, mind, and soul
• Eat more Raw Food! It makes your body Alkaline, improves immune system, and prevents sickness
• Embrace a raw food life style! to become a vibrant being, a vibrant -living body, mind, and soul!

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