Alternative Prostate Cancer Treatment
With Curative Intent

Prostate Cancer Treatment Results

Response Rate of Prostate Cancer Patients

LETTERS

Prostate cancer prospects

AFTER READING YOUR REPORT "PROState Patients’ Painful Choices" [October 16], I feel compelled to inform you of our results. Using radiation combined with hyperthermia (heat) we have not only achieved a better cure rate than either surgery or radiation alone but not a single patient has developed erection difficulty. Indeed, two thirds of the patients report significant increase in both sexual functions and libido. Since the threat of impotence often deters men from accepting treatment, elimination of that prospect will significantly lower the mortality rate for prostate cancer.

James  I. Bicher, M.D., Ralph S. Wolfstein, M.D., Boris Burmistrovich, M.D., Tressia Keen, M.N.

Valley Cancer Institute, Los Angeles, California, U.S.A .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

SUMMARY Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

From the period since 1992 until 2008, 47 patients with primary prostate cancer were treated at the Valley Cancer Institute. This group was treated with local hyperthermia and low radiation dose therapy (IMRT in the last year).

Thirty of them had disease in a comparably early stage, with local and/or regional involvement but no disseminated metastatic disease. In this group of patients we experienced a complete response (CR) rate of 100%. There was one local recurrence and no metastatic dissemination. All these patients experienced a decrease in PSA results, disappearance or significant improvement of local symptoms and preservation or improvement of sexual function .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Another group of seven patients presented with disease in advanced stage. In this group we experienced local response rate: 80% complete response (CR), and 20% partial response (PR). However all these patients presented with or developed later distant metastatic disease. A decrease in the PSA was observed in 40% of these patients, and local symptoms improved significantly or disappeared in all cases. However, this entire group has expired .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

During the course of therapy patients experienced no major side-effects, except minor symptoms of bowel irritation and some degree of skin reaction in the perineal region .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

This study confirms the value of hyperthermia in conjunction with radiation therapy to control locally advanced prostate cancer, especially in its early stages .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Thermoradiotherapy proves to be useful in later stages to improve local symptomatology, especially pain and urinary retention, without significant side-effects .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Introduction Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Results of radiotherapy for prostatic carcinoma have been excellent with mostly acceptable side effects (1,2,3). Can they be improved with the addition of hyperthermia? Published comparison studies on tumors at other sites show a thermal enhancement ratio (TER) of 1.88 with no increase in toxicity, except for occasional thermal burns. It has been our general impression that toxicity may actually be less with the addition of hyperthermia than might be anticipated from the same dose of radiation alone.

Herein our preliminary results using thermoradiotherapy for prostate cancer are presented.

Method and Materials Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Twenty seven patients with prostatic cancer were treated with thermoradiotherapy between 1/92 and 10/00. These men ranged in age from 56 to 78. Eight patients had disease probably confined to the prostate gland. Five had invasion beyond the gland and/or metastatic disease. Radiotherapy was delivered through opposing anterior and posterior portals, 90 cGy to each daily using a MV linear accelerator. The pelvis received 45 Gy and the prostate was boosted to 65 Gy in 8 weeks on average.

Hyperthermia was delivered within one hour before or after each radiotherapy fraction using ultrasound or 300 MHz Microwave equipment alternately. Ultrasound was directed to the gland and mid pelvis, microwave to the prostate.

Results Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Twenty of the twenty seven patients treated had disease in a comparably early stage, with local and /or regional involvement but no disseminated metastatic disease. In this group of patients we experienced a complete response (CR) rate of 100%. There was no local recurrence or metastatic dissemination. All these patients experienced a decrease in PSA results, disappearance or significant improvement of local symptoms and preservation or improvement of sexual function (see table).

Another group of five patients presented with more advanced disease. In this group we experienced a local response rate as follows: 80% complete response (CR), and 20% partial response (PR). However all these patient presented with or developed later distant metastatic disease. A decrease in the PSA was observed in 40% of these patients, and local symptoms improved significantly or disappeared in all cases. All 5 of these patients eventually expired.

During the course of therapy patients experienced no major side-effects, except minor symptoms of bowel irritation and some degree of skin reaction in the perineal region .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

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