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James Bicher MD
James Bicher MD -
  Bicher Cancer
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Acupuncture Back Pain Los Angeles
James I. Bicher MD 
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James Bicher MD
   Hyperthermia Treatment

Alternative Prostate Cancer Treatment Options
With Curative Intent and Low Sexual Side Effects

Hyperthermia combined with Low-Dose-Radiation:
A very effective Prostate Cancer Treatment with Low or no Sexual Side Effects.

One of the main concerns of men and women, is How about sex after prostate cancer treatment?"
The response rate or success of Hyperthermia combined with low-dose-radiation on the treatment of Prostate Cancer is about 95% for early stages. Only 9% of our patients reported Erectile Dysfunction that leads to impotence, while prostate cancer patients treated with conventional radiation therapy have an incidence of Erectile Dysfunction of about 30 to 60 %. See below a scientific paper presented by James Bicher MD, founder and Director of Valley Cancer Institute / Bicher Cancer Institute, on
Hyperfractionated Thermoradiotheray (HTRT) Causes Less Sexual Dysfunction , in the international 2010 STM, Society for Thermal Medicine, meeting.

The following tables are the latest results on Prostate Cancer Treatment options with curative intent, from 2004 to February 2010. at the Valley Cancer institute under the direction of Dr. James I. Bicher. These effective results had  been consistent on Prostate Cancer Treatment, with the application of Hyperthermia and low dose radiation therapies, since the creation of the institute in 1884.

Sexual Side Effects of conventional Prostate Cancer treatments like surgery, followed by high dose radiation and chemotherapy are very well known: loss of libido, impotence, incontinence, and diarrhea.

As a wife of one of our patients said in the video testimonial below: "With conventional Prostate Cancer Treatment you can have Impotence, Incontinence, and Diarrhea. Who wants to have those when you don't need it!" They were able to have a normal sexual life after prostate cancer treatment!

This modality/option of cancer treatment, named Thermoradiotherapy, has been improved and enhanced by the use of a very localized radiation therapy in the form of IMRT (Intensity modulated Radiation Therapy) which focuses the low radiation dose only to the cancer tumor area, protecting the healthy tissue, and makes it an important option on Prostate Cancer Treatment.


Prostate
Cancer Treatment Results
 

Response Rate of Prostate Cancer Patients

 


Picture of a PSA Report after 14 weeks of Hyperthermia Treatment combined with low-dose-radiation.


Press Release: US News & WORLD REPORT, Magazine: Prostate cancer prospects Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.
Article published in the US News magazine, November 19th, 2006, written by Valley Cancer Institute medical staff, Dr Ralph S. Wolfstein

LETTERS

Prostate cancer prospects

AFTER READING YOUR REPORT "PROState Patients’ Painful Choices" [October 16], I feel compelled to inform you of our results. Using radiation combined with hyperthermia (heat) we have not only achieved a better cure rate than either surgery or radiation alone but not a single patient has developed erection difficulty. Indeed, two thirds of the patients report significant increase in both sexual functions and libido. Since the threat of impotence often deters men from accepting treatment, elimination of that prospect will significantly lower the mortality rate for prostate cancer.
 

From being confused, scared, and angry, to being prostate cancer free! A moving and real testimonial, from a courageous men who did not accepted his primary doctor options' of surgery, high dose radiation, and/or chemotherapy. Instead, he fully took responsibility of his health, and become an informed person, by looking and researching in the internet for a better-low sexual side effects prostate cancer treatment alternative. Look at his PSA tumor marker before and after treatment at the bottom of this page.
Watch Parts II and III in our You Tube channel:
http://www.youtube.com/alternativecancertre
 

Watch this  amazing testimony from one of our prostate cancer patients, who went from the "cutting, poisoning and burning..." treatment options from his primary doctor, to "the gentle heat hyperthermia treatment..." that got him cured! He drove back home for 5 days, when he finished his treatment! Hyperthermia do not makes you sick, but you get better and better during the progress of the treatment, until your treatment is finished.

 

"Who wants the side effects of impotence, incontinence, and diarrhea when you don't have to!", the wife of this patient said...
On this video testimony you will find a very REAL story of one of our "graduated" patients, who after being offered the standard cancer treatment care of surgery, high radiation dose, and chemotherapy, him and his wife decided to look for something without the permanent side effects of that options.

 

 
This is the transcript of the above video testimony, for you to read and enjoy!:

CDC:                I have the previous interview patients who are living like you, but I always meet them where they are living. It’s a pity, because I like to talk to people like you. Could you please tell us, how did you find us?  How did you find Valley Cancer Institute?   

Patient:            Well, basically, through a friend. We had a friend that was looking for a treatment for his wife and he talked to Dr. Wolfstein, and happened to mention that he had a friend that had my prostate cancer, and Dr. Wolfstein said, “He should call me, because I think we can help him”. So, that’s basically how we found the institute.

 CDC:                And, when you were diagnosed, what did you do?  Did you go to your primary doctor for?  

Patient:            Yes, when we first found out that my PSA had risen, it was through my, through a regular physical. I had a PSA and it was quite high. It was in October and it was a 7.8, October of 08. So at that time, he suggested that we contact an urologist and have it checked out.  

CDC:                I see. We have the pleasure to have your wife here, too. I know that this is a little personal, but what was your reaction when you knew that your husband had prostate cancer?  

Mrs. S:             Well, he had always been so healthy. We had no idea that he had cancer. We were both shocked. So I started, we talked to the doctors and got their opinions as to what they thought was should do, and then I went on the internet and I started examining and all of that. Then after we talked to Dr. Wolfstein, then he told me where to look on the internet and I looked up the website and I got the information from that. I started examining hyperthermia on the website, and we never had considered alternative medicine before, because we were very traditional people in our medicines. We didn’t go into health foods. We didn’t look into any of those things. We knew people who did and we weren’t against it, but it just wasn’t what we had done. But we heard about all the side effects that come from the traditional medicines and neither one of us liked any of those side effects. So we thought this sounded very interesting.  

CDC:                And then that’s what primarily decided you to come here?  Did they say the effect of hyperthermia was what made you decide to come here?  

Patient:            Yes. We thought this would be a very interesting, the use of radiation as well as hyperthermia. It would be a low dose, so it would take a longer period of time, but it would not be, like my wife said, as many side effects. So that’s really primarily why we decided on the institute here.  

CDC:                And it was the very first time that you heard about hyperthermia when you came to our website?  

Mrs. S:             Yeah. I had never heard it. I had heard of it, but just kind of off for other people. I never considered it for ourselves, but like a Patient said, the combining of both the hyperthermia with the low dose radiation sounded very intriguing. It sounded like maybe this, and it’s being used in Germany and in Europe.  

CDC:                 And you knew that?  

Mrs. S:             Well, not until I started looking into it, not until Dr. Wolfstein told me about it. I researched it in Europe to see what they were doing there and I know that the FDA keeps people from getting things as readily here as in Europe. So I figured, hey, if it’s there and it’s valuable. I need to look into it.  

CDC:                So you said that it was very intriguing, but were you, did you also do some research on the treatment results of hyperthermia?  

Mrs. S:             Yes. That was what was convincing, because we didn’t want (the sexual) side effects, but we wanted a cure.  

CDC:                Of course!  

Mrs. S:             You know, it wasn’t just the side effects that made us choose this.  

CDC:                So you, from the very beginning, you found our place. Did you go through the alternatives that your primary doctor gave you?  What did they offer you?  

Patient:            We actually visited probably four to five different things that we could do that would be available to us. One was surgery and one was, of course, the radiation, and then there was a chemotherapy, which we decided against. So, there were a number of things that was open to us, but after investigating them all, we decided that they all had very strong side effects that we would like, not like to have. So anyway that’s really one of the primary reasons we decided on the institute here.  

Mrs. S:             He had scheduled surgery. He was scheduled for surgery about four days after we visited here. So, we had to cancel the surgery, but we had a friend who did have the surgery and nine months later the cancer came back, plus he has to live with the side effects for the rest of his life. We figured, boy, we’ve got to give something else a try.  

CDC:                That’s very interesting. Now that you have been through the treatment, how can you describe, if you had to talk to someone who never heard about hyperthermia, how is the treatment?  Was it comfortable?  Was it hard to take?   

Patient:            No, the treatment actually is painless. The radiation is painless. The people in radiation are very thorough. The hyperthermia takes 45 minutes and it’s done through a heat treat that does no pain to it. So there’s no pain to the treatment at all. It just takes time and, of course, if you have the time, it’s very good.  

CDC:                Because I hear from other patients and other people, they say when you go through the standard care of treatment, which usually is chemotherapy, radiation, and surgery, after the procedure itself, you don’t feel very well. So, the contrast with hyperthermia, how do you feel as the treatment progressed week by week?  

Patient:            Actually, I had no illness at all; except it does make you a little more tired by the end of the day, but that was, actually, the only thing I ever noticed.  

CDC:                That’s fantastic. You just finished the treatment a week ago, last week.  

Patient:            Yes.  

CDC:                 Do you have any side effects?  

Patient:            No, not at all.  

CDC:                That’s fantastic. You mentioned already that you didn’t’ do any special diet. You were just regular people.  

Patient:            And, actually, we have never done any special diet. We’re kind of traditional people that, this is the first time we’ve done anything different other than the traditional way of doing things.  

CDC:                Do you know if I have any other questions?  

Patient:            Anything I’d like to ask?  

Mrs. S:             One thing is that the side effects from prostate cancer, the treatment that the traditional medicine uses, are, you can be impotent, you can be incontinent, you can have constantly diarrhea for the rest of your life, and who wants to live with that if you don’t’ have to?  Everything is working just great, so we’re really glad, plus it’s gone.  

Patient:            Yeah, we’re very happy.  

CDC:                That’s very interesting. When you, you said at the beginning that the hyperthermia sounds, I don’t remember exactly the word that you used, but very interesting. Did you still have doubts about this kind of treatment or after the research that you did, you saw that it was done in Germany, the resources you had gave you confidence?  

Mrs. S:             When we first came here, we were still a little skeptical, but we figured it doesn’t hurt to try and see what happened. Then when we came here we started talking to people and all the good results people have had, it built up our confidence in it, and then, of course, getting the PSA results through the months, that continued making us say, “Hey, look!  It’s going down!” So that’s really been proven to be the best thing we could have done.  

CDC:                Alright. Do you think you can describe how do you feel physically and emotionally now after the treatment is done, compared to when you were diagnosed?  

Patient:            Well, I’d have to say I was quite upset when I first found out that I had Prostate Cancer. That’s something that I knew a lot of men had gotten after they up in age. I’m 76 now and my father had it. Of course, he never had been treated. Since we have a family of longevity, I thought at 76 that we should do something about this, because I think I’m in good physical health, so I think we should do something about it that would be positive. This fit the bill just fine. At the end of the treatment, I’m very happy. I couldn’t be happier.  

CDC:                All right. Thank you so much for answering these questions. The main reason we are doing that is because some other people will see what you have to say and maybe we can help them.  

Patient:            I hope so.  

CDC:                Thank you so much.


PSA Repot after 14 weeks of treatment!

This is a PSA report, (a tumor marker that measures the cancer activity on the prostate area), of one actual patient at the time of the posting, 05-25-10.
PSA is an indication of the cancer activity in the prostate. High levels of PSA in the blood, means there is a cancer activity in the prostate.

The graph, circled on red, shows how the PSA dropped from about 8 to 10 before the treatment, to 0.6 (normal) after 14 weeks of treatment

Prostate Cancer Treatment-PSA


Thermoradiotherapy with curative intent (last published scientific paper, in the German Journal Of Hyperthermia)

Hyperfractionated Thermoradiotheray (HTRT) Causes Less Sexual Dysfunction than External Beam Radiation Therapy (EBRT) in Definitive Treatment of Prostate Cancer

 James I, Bicher, M.D., Ralph S. Wolfstein, M.D.

Valley Cancer Institute, Los Angeles, California

             Treatment modalities for early stage prostate cancer (surgery, EBRT or brachytherapy) have a similar degree of effectiveness (over 90% 5-year survival), thus, preservation of sexual function becomes an important criteria for modality selection.

             We have compared the results of published data (1) (2) (3) on the percentage of erectile dysfunction (ED) in patients treated successfully with EBRT with that of 5-year survivors in our institution following hyperfractionated thermoradiotherapy (HTRT). As previously described the HTRT technique consists of decreasing daily doses of EBRT combined with daily hyperthermia treatments delivered using a Labthermics Ultrasound Machine. 

            Published results report an incidence of erectile dysfunction between 30 to 60 per cent following EBRT.  In our series of 22 patients treated, only 2 reported ED leading to impotence, amounting to 10% of 5-year survivors.  In most cases patients and their spouses reported increased sexual activity.

 Conclusion: Hyperfractionated radiotherapy seems to cause less complications of sexual dysfunction than external beam radiation therapy.  We consider the institution of randomized trials to study this concept warranted.

 1          Siglin et al- Int J. Radiation Onc.. Biol. Physics 76;31-35  2010

 2          Sanda et al- N. Engl J. Med 358 1250-1261 2008

 3          Pinkawa et al EUR UROL 55 217-236 2009

 4          Bicher et al-German Journal of Onc. 33:116-122 2006


The following is a paper presented by Dr. James Bicher at an ICHS (International Clinical Hyperthermia Society) meeting.

THERMORADIOTHERAPY FOR PROSTATE CANCER

James  I. Bicher, M.D., Ralph S. Wolfstein, M.D., Boris Burmistrovich, M.D., Tressia Keen, M.N.

Valley Cancer Institute, Los Angeles, California, U.S.A .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

SUMMARY Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

From the period since 1992 until 2008, 47 patients with primary prostate cancer were treated at the Valley Cancer Institute. This group was treated with local hyperthermia and low radiation dose therapy (IMRT in the last year).

Thirty of them had disease in a comparably early stage, with local and/or regional involvement but no disseminated metastatic disease. In this group of patients we experienced a complete response (CR) rate of 100%. There was one local recurrence and no metastatic dissemination. All these patients experienced a decrease in PSA results, disappearance or significant improvement of local symptoms and preservation or improvement of sexual function .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Another group of seven patients presented with disease in advanced stage. In this group we experienced local response rate: 80% complete response (CR), and 20% partial response (PR). However all these patients presented with or developed later distant metastatic disease. A decrease in the PSA was observed in 40% of these patients, and local symptoms improved significantly or disappeared in all cases. However, this entire group has expired .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

During the course of therapy patients experienced no major side-effects, except minor symptoms of bowel irritation and some degree of skin reaction in the perineal region .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

This study confirms the value of hyperthermia in conjunction with radiation therapy to control locally advanced prostate cancer, especially in its early stages .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Thermoradiotherapy proves to be useful in later stages to improve local symptomatology, especially pain and urinary retention, without significant side-effects .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Introduction Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Results of radiotherapy for prostatic carcinoma have been excellent with mostly acceptable side effects (1,2,3). Can they be improved with the addition of hyperthermia? Published comparison studies on tumors at other sites show a thermal enhancement ratio (TER) of 1.88 with no increase in toxicity, except for occasional thermal burns. It has been our general impression that toxicity may actually be less with the addition of hyperthermia than might be anticipated from the same dose of radiation alone.

Herein our preliminary results using thermoradiotherapy for prostate cancer are presented.

Method and Materials Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Twenty seven patients with prostatic cancer were treated with thermoradiotherapy between 1/92 and 10/00. These men ranged in age from 56 to 78. Eight patients had disease probably confined to the prostate gland. Five had invasion beyond the gland and/or metastatic disease. Radiotherapy was delivered through opposing anterior and posterior portals, 90 cGy to each daily using a MV linear accelerator. The pelvis received 45 Gy and the prostate was boosted to 65 Gy in 8 weeks on average.

Hyperthermia was delivered within one hour before or after each radiotherapy fraction using ultrasound or 300 MHz Microwave equipment alternately. Ultrasound was directed to the gland and mid pelvis, microwave to the prostate.

Results Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Twenty of the twenty seven patients treated had disease in a comparably early stage, with local and /or regional involvement but no disseminated metastatic disease. In this group of patients we experienced a complete response (CR) rate of 100%. There was no local recurrence or metastatic dissemination. All these patients experienced a decrease in PSA results, disappearance or significant improvement of local symptoms and preservation or improvement of sexual function (see table).

Another group of five patients presented with more advanced disease. In this group we experienced a local response rate as follows: 80% complete response (CR), and 20% partial response (PR). However all these patient presented with or developed later distant metastatic disease. A decrease in the PSA was observed in 40% of these patients, and local symptoms improved significantly or disappeared in all cases. All 5 of these patients eventually expired.

During the course of therapy patients experienced no major side-effects, except minor symptoms of bowel irritation and some degree of skin reaction in the perineal region .Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

 LOCAL PROSTATE CANCER PATIENTS

TREATED WITH RADIATION ! 65 Gy ! + HYPERTHERMIA

( PERIOD FROM 1992 TO 2000 )

TOTAL # OF TREATED PATIENTS:  47

EARLY  DISEASE: 20
   #       (%)

ADVANCED DISEASE: 7
  #     (%)

COMPLETE RESPONSE

20 (100)

4 (80)
PARTIAL RESPONSE 0 (0) 3 (20)
LOCAL RECURRENCE 1 (5) 0 (0)
DISTANT METASTASIS 1 (5) 7 (100)
 

SEXUAL FUNCTION

 

Increase

13 (66)

NO FOLLOW UP

Decrease

0 (0) -

No change

7 (33) -
 

PSA AFTER TREATMENT   (FOLLOW UP UNTIL 2000 OR UNTIL PATIENT EXPIRED)

 

Increase

0 (0) 4 (60)

Decrease

20 (100) 0 (0)
No change 0       0) 3 (40)
PATIENTS ALIVE AT PRESENT TIME (LENGTH OF FOLLOW UP: 1 TO 3 YEARS) 20 (100) 0 (0)
SYMPTOMS IMPROVED AFTER TREATMENT COMPLETE 18 (91) 7 (100)
PARTIAL 2 (9) 0 (0)

Discussion Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

This study confirms the value of hyperthermia in conjunction with radiation therapy to control locally advanced prostate cancer, especially in its early stages. Thermoradiotherapy proves to be useful in later stages to improve local symptomatology, especially pain and urinary retention, without significant side-effects. Tumor grade has also not shown any correlation. It was of interest that the one patient who had distant metastasis was the only patient who failed to have complete local tumor regression.

Survival has been short in all five patients with advanced disease, but 2 deaths were unrelated to cancer. Survival of the others cannot, of course, be predicted; however, the improvement in their sex lives is striking. Radiotherapy has never been reported to improve sexual function. A recent report on 53 men given radiotherapy for prostate cancer found 77% had decreased sexual desire as well as function.

References Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

1. Beiler, D.E.; Wright, D.J.; Reddy, G.N. "Radical external radiotherapy for prostatic carcinoma". International Journal of Radiation Biological Physics. 7: 885-890; 1981.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

2. Hahn, P.; Baral, E.; Cheang,M.; Math, M.; Kostyra, J.; Roelss, R. "Long -term outcome of radical radiation therapy for prostatic carcinoma: 1967 - 1987" . International Journal of Radiation Biological Physics. 34: 41-47; 1996.

3. Harisiadis, D.; Veeneng, R.J.; Senyzyn, J.J.; Puchner, P.J.; Tretter, P; Romas, N.A.; j Chang, C.H.j.; Lattiment, J.K.; Tannenbaum, M. "Carcinoma of the prostate: Treatment with external radiotherapy". Cancer 41: 2131-2142; 1978.

4. Bicher, H.I.; Wolfstein, R.S. "Clinical use of regional hyperthermia". In: Bicher, H.I. Consensus on Hyperthermia for the 1990's : 1-20; New York: Plenum Press; 1990.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.

5. Helgason, A.R.; Fredrikson, M.; Adolfsson, J.; Steineck, G.. "Decreased sexual capacity after external radiation therapy for prostate cancer impairs quality of life". International Journal of Radiation Biological Physics 32: 33-39; 1995.


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