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ADENOCARCINOMA / AIDS LYMPHOMA / BREAST /BRAIN TUMOR Press Realese: US News & WORLD
REPORT, Magazine: Prostate cancer prospectsAlternative
cancer treatment, alternative breast cancer treatment, alternative prostate cancer
treatment. THERMORADIOTHERAPY FOR PROSTATE CANCER James I. Bicher, M.D., Ralph S. Wolfstein, M.D., Boris Burmistrovich, M.D., Tressia Keen, M.N.Valley Cancer Institute, Los Angeles, California, U.S.A.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. SUMMARYAlternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. From the period since 1992 until 2000, 27 patients with primary prostate cancer were treated at the Valley Cancer Institute. This group was treated with external beam radiation therapy and local hyperthermia. Twenty of them had disease in a comparably early stage, with local and/or regional involvement but no disseminated metastatic disease. In this group of patients we experienced a complete response (CR) rate of 100%. There was one local recurrence and no metastatic dissemination. All these patients experienced a decrease in PSA results, disappearance or significant improvement of local symptoms and preservation or improvement of sexual function.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. Another group of seven patients presented with disease in advanced stage. In this group we experienced local response rate: 80% complete response (CR), and 20% partial response (PR). However all these patients presented with or developed later distant metastatic disease. A decrease in the PSA was observed in 40% of these patients, and local symptoms improved significantly or disappeared in all cases. However, this entire group has expired.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. During the course of therapy patients experienced no major side-effects, except minor symptoms of bowel irritation and some degree of skin reaction in the perineal region.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. This study confirms the value of hyperthermia in conjunction with radiation therapy to control locally advanced prostate cancer, especially in its early stages.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. Thermoradiotherapy proves to be useful in later stages to improve local symptomatology, especially pain and urinary retention, without significant side-effects.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. IntroductionAlternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. Results of radiotherapy for prostatic carcinoma have been excellent with mostly acceptable side effects (1,2,3). Can they be improved with the addition of hyperthermia? Published comparison studies on tumors at other sites show a thermal enhancement ratio (TER) of 1.88 with no increase in toxicity, except for occasional thermal burns. It has been our general impression that toxicity may actually be less with the addition of hyperthermia than might be anticipated from the same dose of radiation alone. Herein our preliminary results using thermoradiotherapy for prostate cancer are presented. Method and MaterialsAlternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. Twenty seven patients with prostatic cancer were treated with thermoradiotherapy between 1/92 and 10/00. These men ranged in age from 56 to 78. Eight patients had disease probably confined to the prostate gland. Five had invasion beyond the gland and/or metastatic disease. Radiotherapy was delivered through opposing anterior and posterior portals, 90 cGy to each daily using a MV linear accelerator. The pelvis received 45 Gy and the prostate was boosted to 65 Gy in 8 weeks on average. Hyperthermia was delivered within one hour before or after each radiotherapy fraction using ultrasound or 300 MHz Microwave equipment alternately. Ultrasound was directed to the gland and mid pelvis, microwave to the prostate. ResultsAlternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. Twenty of the twenty seven patients treated had disease in a comparably early stage, with local and /or regional involvement but no disseminated metastatic disease. In this group of patients we experienced a complete response (CR) rate of 100%. There was no local recurrence or metastatic dissemination. All these patients experienced a decrease in PSA results, disappearance or significant improvement of local symptoms and preservation or improvement of sexual function (see table). Another group of five patients presented with more advanced disease. In this group we experienced a local response rate as follows: 80% complete response (CR), and 20% partial response (PR). However all these patient presented with or developed later distant metastatic disease. A decrease in the PSA was observed in 40% of these patients, and local symptoms improved significantly or disappeared in all cases. All 5 of these patients eventually expired. During the course of therapy patients experienced no major side-effects, except minor symptoms of bowel irritation and some degree of skin reaction in the perineal region.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment.LOCAL PROSTATE CANCER PATIENTS TREATED WITH RADIATION ! 65 Gy ! + HYPERTHERMIA ( PERIOD FROM 1992 TO 2000 )
 Alternative cancer treatment, alternative
breast cancer treatment, alternative prostate cancer treatment.
This study confirms the value of hyperthermia in conjunction with radiation therapy to control locally advanced prostate cancer, especially in its early stages. Thermoradiotherapy proves to be useful in later stages to improve local symptomatology, especially pain and urinary retention, without significant side-effects. Tumor grade has also not shown any correlation. It was of interest that the one patient who had distant metastasis was the only patient who failed to have complete local tumor regression. Survival has been short in all five patients with advanced disease, but 2 deaths were unrelated to cancer. Survival of the others cannot, of course, be predicted; however, the improvement in their sex lives is striking. Radiotherapy has never been reported to improve sexual function. A recent report on 53 men given radiotherapy for prostate cancer found 77% had decreased sexual desire as well as function.
Picture of Ultrasound Hyperthermia machine, used in prostate cancer treatment ReferencesAlternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. 1. Beiler, D.E.; Wright, D.J.; Reddy, G.N. "Radical external radiotherapy for prostatic carcinoma". International Journal of Radiation Biological Physics. 7: 885-890; 1981.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. 2. Hahn, P.; Baral, E.; Cheang,M.; Math, M.; Kostyra, J.; Roelss, R. "Long -term outcome of radical radiation therapy for prostatic carcinoma: 1967 - 1987" . International Journal of Radiation Biological Physics. 34: 41-47; 1996. 3. Harisiadis, D.; Veeneng, R.J.; Senyzyn, J.J.; Puchner, P.J.; Tretter, P; Romas, N.A.; j Chang, C.H.j.; Lattiment, J.K.; Tannenbaum, M. "Carcinoma of the prostate: Treatment with external radiotherapy". Cancer 41: 2131-2142; 1978. 4. Bicher, H.I.; Wolfstein, R.S. "Clinical use of regional hyperthermia". In: Bicher, H.I. Consensus on Hyperthermia for the 1990's : 1-20; New York: Plenum Press; 1990.Alternative cancer treatment, alternative breast cancer treatment, alternative prostate cancer treatment. 5. Helgason, A.R.; Fredrikson, M.; Adolfsson, J.; Steineck, G.. "Decreased sexual capacity after external radiation therapy for prostate cancer impairs quality of life". International Journal of Radiation Biological Physics 32: 33-39; 1995.
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